01 - Whisk together buttermilk, salt, black pepper, garlic powder, and paprika in a large bowl. Add chicken breasts and coat evenly. Cover and refrigerate for at least 30 minutes.
02 - In a shallow dish, mix flour, panko breadcrumbs, paprika, cayenne pepper, oregano, salt, and black pepper.
03 - Remove chicken from marinade, letting excess drip off. Dredge each piece thoroughly in flour mixture, pressing gently to adhere.
04 - Warm vegetable oil in a large nonstick or cast-iron skillet over medium-high heat.
05 - Place chicken breasts in skillet and cook 5–6 minutes per side until golden brown and internal temperature reaches 165°F. Adjust heat to prevent burning.
06 - Transfer chicken to paper towel-lined plate to drain excess oil. Allow to rest 5 minutes before serving.